2021 MLS Expansion Draft Transactions
December 14, 2021
The 2021 MLS expansion draft was held to stock the roster of expansion team Charlotte FC. Charlotte FC was allowed to draft 5 players— 1 player from each of 5 different teams which did not have players drafted from their roster in the 2020 MLS expansion draft.
| Overall # | Team | Player Drafted |
| 1 |  Charlotte FC |
McKinze Gaines |
| 2 | Charlotte FC |
Anton Walkes |
| 3 | Charlotte FC |
Joseph Mora |
| 4 | Charlotte FC |
Tristan Blackmon |
| 5 | Charlotte FC |
Ismael Tajouri-Shradi |